Do down syndrome adults develop alzheimers

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Down syndrome often comes with intellectual and developmental disabilities, and patients are at risk for a number of health issues. Sticky clumps of that very same protein accumulating in the brain is a well-known characteristic of Alzheimer's, Hithersay added. That said, many will.

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More research projects. Our genetic information is stored in 23 pairs of genetic units called chromosomes that can each contain hundreds, or even thousands, of genes. One of the genes on chromosome 21 codes for the Amyloid Precursor Protein APPwhich produces a protein called amyloid.

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His Superman T-shirt was bold and bright, but his face was creased with confusion. Gerry Thomas was stumped by a question most men can answer in an instant. Thomas, 50, sitting in the house he and his sister share in Queens, squinted with intense concentration.

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Scientists believe the increased risk is due to the extra chromosome, chromosome 21, that causes Down syndrome. Persons born with Down syndrome have three copies instead of the normal two copies of this chromosome. Scientists have identified several genes on chromosome 21 that are responsible for certain aspects of the aging process.

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If you have concerns about the person for whom you care, the first step is to talk to their GP. This is why it is especially important to be careful and thoughtful about assigning this diagnosis before looking at all other possible causes for why changes are taking place with ageing. Since these are treatable, it is vitally important to have a full medical assessment at an early stage in order to rule them out.

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Neuropathology consistent with AD is present by 40 years of age and dementia may develop up to a decade later. In this review, we describe metabolic and vascular neuroimaging studies in DS that suggest these functional changes are a key feature of aging, linked to cognitive decline and AD in this vulnerable cohort. Magentic resonance spectroscopy studies show consistent decreases in neuronal health and increased myoinositol, suggesting inflammation.

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A study that I am involved in, called LonDowNsis now trying to find out why this may be, with the hope of finding ways to slow down the development of dementia. Apart from age, other factors can increase the risk of an individual developing the condition. Some of these are lifestyle-related, such as smoking, diabetes or high blood pressure.

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Jon Hamilton. Benjamin B. Morris for NPR hide caption. When researchers at the University of California, San Diego wanted to study an experimental Alzheimer's drug last year, they sought help from an unlikely group: people with Down syndrome.

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DOI: The series features reviews by experts in neuroscience and aims to provide current information in the field to both researchers and clinicians. Down syndrome is a chromosomal disorder affecting more than 5.

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Intellectual disability, delayed growth, muscular weakness and distinctive facial features are the main characteristics but, with the appropriate education and support, people with DS can develop employable skills and live independent, rewarding lives. With careful monitoring, most of these conditions can be treated and, as a result, average life expectancy has increased to over 60 years. These protein abnormalities block neuron connections, eventually leading to neuron death and brain tissue loss. Ultimately, long-term brain deterioration stimulates dementia onset, which involves symptoms such as memory loss, personality changes, problems with language and confusion.

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