Cutaneous metastisis of breast cancer

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Cutaneous metastases can have variable clinical appearances and can mimic benign skin lesions. They are usually seen in patients with advanced disease, but they can be the presenting lesion. A year-old woman presented with a 3-month history of progressive appearance of multiple asymptomatic nodular lesions on the chest.

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App to facilitate skin self-examination and early detection. Read more. In most cases, cutaneous metastasis develops after the initial diagnosis of the primary internal malignancy such as breast cancer and lung cancer and late in the course of the disease.

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What are skin metastases? Symptoms of skin metastases 3. What tests might I need?

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Breast cancer is the second most common malignancy after melanoma to metastasize to skin. Progression of disease often results in severe pain, chest wall ulceration, bleeding, and superinfection. Apart from improving quality of life, recent evidence suggests that skin-directed treatment of CMOBC with topical imiquimod can provide durable systemic responses that prolong survival. All patients had striking responses both locally and systemically.

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Background: The management of breast cancer BC skin metastases represents a therapeutic challenge. Electrochemotherapy ECT combines the administration of bleomycin with temporary permeabilization induced by locally administered electric pulses. The treatment was administered following the European Standard Operative Procedures of Electrochemotherapy.

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Metastasis is defined as a neoplastic lesion originating from another primary tumor, with which it is no longer in contact. Cutaneous metastases result from lymphatic embolization, hematogenous or contiguous dissemination or also direct implantation during surgical procedures. In women, the tumor most likely to metastasize to skin is breast cancer, which may manifest as papulonodular neoplastic lesions.

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Breast carcinoma is the most common malignancy encountered in clinical practice presenting with cutaneous metastasis CM. CM all over the body with involvement of eyelids is very rare. Here, we present a case series of three patients, two with common nodular metastasis to facial skin and one, a rare case of carcinoma breast with multiple diffuse CM all over the body and face involving eyelids.

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A year-old woman develops four painless lumps in the skin of the right arm and trunk. She underwent a lower-outer left quadrantectomy and axillary lymph node dissection, followed by radiotherapy and hormonal therapy. Two years before the patient had a metastatic femoral fracture treated by intramedullary nailing. The cutaneous nodules are less than 1 cm, firm, round, mobile, non-painful and the skin over them is normal.

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Ocular complications of atopic dermatitis. Correspondence: Jonathan E. Cutaneous metastases typically occur in only a small minority of breast cancer patients.

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Cutaneous metastasis is the main cause of morbidity and mortality of cancer patients, denoting a guarded prognosis. The clinical spectrum of the disease is broad and can mimic benign conditions. The diagnosis depends on thorough clinical examination and complementary exams, with emphasis on the histopathological study and immunohistochemistry. Because it indicates a systemic relapse, it is necessary to intervene with intravenous chemotherapy, to which local therapies can be associated.


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